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Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence
Cellular senescence is triggered by various distinct stresses and characterized by a permanent cell cycle arrest. Senescent cells secrete a variety of inflammatory factors, collectively referred to as the senescence-associated secretory phenotype (SASP). The mechanism(s) underlying the regulation of...
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| Publicado no: | Nat Cell Biol |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5826565/ https://ncbi.nlm.nih.gov/pubmed/28759028 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb3586 |
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