Restriction by SAMHD1 Limits cGAS/STING-Dependent Innate and Adaptive Immune Responses to HIV-1

SAMHD1 is a restriction factor for HIV-1 infection. SAMHD1 mutations cause the autoinflammatory Aicardi-Goutières syndrome that is characterized by chronic type I interferon (IFN) secretion. We show that the spontaneous IFN response in SAMHD1-deficient cells and mice requires the cGAS/STING cytosoli...

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Publicado en:Cell Rep
Autores principales: Maelfait, Jonathan, Bridgeman, Anne, Benlahrech, Adel, Cursi, Chiara, Rehwinkel, Jan
Formato: Artigo
Lenguaje:Inglês
Publicado: Cell Press 2016
Materias:
Report
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4978700/
https://ncbi.nlm.nih.gov/pubmed/27477283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.07.002
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