Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence

Cellular senescence is triggered by various distinct stresses and characterized by a permanent cell cycle arrest. Senescent cells secrete a variety of inflammatory factors, collectively referred to as the senescence-associated secretory phenotype (SASP). The mechanism(s) underlying the regulation of...

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Pubblicato in:Nat Cell Biol
Autori principali: Glück, Selene, Guey, Baptiste, Gulen, Muhammet Fatih, Wolter, Katharina, Kang, Tae-Won, Schmacke, Niklas Arndt, Bridgeman, Anne, Rehwinkel, Jan, Zender, Lars, Ablasser, Andrea
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5826565/
https://ncbi.nlm.nih.gov/pubmed/28759028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb3586
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