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The RIG-I ATPase domain structure reveals insights into ATP-dependent antiviral signalling
RIG-I detects cytosolic viral dsRNA with 5′ triphosphates (5′-ppp-dsRNA), thereby initiating an antiviral innate immune response. Here we report the crystal structure of superfamily 2 (SF2) ATPase domain of RIG-I in complex with a nucleotide analogue. RIG-I SF2 comprises two RecA-like domains 1A and...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3207106/ https://ncbi.nlm.nih.gov/pubmed/21979817 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2011.190 |
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