Crystal and solution structure of the human RIG-I SF2 domain

RIG-I is a pathogen-recognition receptor that recognizes viral 5′-triphosphates carrying double-stranded RNA. Upon binding to these microbe-associated molecular patterns (MAMPs), RIG-I forms oligomers and promotes downstream processes that result in type I interferon production and induction of an a...

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Bibliographic Details
Main Authors: Deimling, Tobias, Cui, Sheng, Lammens, Katja, Hopfner, Karl-Peter, Witte, Gregor
Format: Artigo
Language:Inglês
Published: International Union of Crystallography 2014
Subjects:
Structural Communications
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4118797/
https://ncbi.nlm.nih.gov/pubmed/25084375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S2053230X14012230
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