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Unified mechanisms for self-RNA recognition by RIG-I Singleton-Merten syndrome variants
The innate immune sensor retinoic acid-inducible gene I (RIG-I) detects cytosolic viral RNA and requires a conformational change caused by both ATP and RNA binding to induce an active signaling state and to trigger an immune response. Previously, we showed that ATP hydrolysis removes RIG-I from lowe...
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| Publicado no: | eLife |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
eLife Sciences Publications, Ltd
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6086658/ https://ncbi.nlm.nih.gov/pubmed/30047865 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.38958 |
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