The regulatory domain of the RIG-I family ATPase LGP2 senses double-stranded RNA

RIG-I and MDA5 sense cytoplasmic viral RNA and set-off a signal transduction cascade, leading to antiviral innate immune response. The third RIG-I-like receptor, LGP2, differentially regulates RIG-I- and MDA5-dependent RNA sensing in an unknown manner. All three receptors possess a C-terminal regula...

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Detalhes bibliográficos
Main Authors: Pippig, Diana A., Hellmuth, Johannes C., Cui, Sheng, Kirchhofer, Axel, Lammens, Katja, Lammens, Alfred, Schmidt, Andreas, Rothenfusser, Simon, Hopfner, Karl-Peter
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2009
Assuntos:
Structural Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2665237/
https://ncbi.nlm.nih.gov/pubmed/19208642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp059
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