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Cytosolic viral sensor RIG-I is a 5′-triphosphate dependent translocase on double stranded RNA
RIG-I is a cytosolic multi-domain protein that detects viral RNA and elicits an antiviral immune response. Two N-terminal caspase activation and recruitment domains (CARDs) transmit the signal and the regulatory domain prevents signaling in the absence of viral RNA. 5′-triphosphate and double strand...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3567915/ https://ncbi.nlm.nih.gov/pubmed/19119185 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1168352 |
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