The RIG-I-like Receptor LGP2 Recognizes the Termini of Double-stranded RNA

The RIG-I-like receptors (RLRs), RIG-I and MDA5, recognize single-stranded RNA with 5′ triphosphates and double-stranded RNA (dsRNA) to initiate innate antiviral immune responses. LGP2, a homolog of RIG-I and MDA5 that lacks signaling capability, regulates the signaling of the RLRs. To establish the...

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Detalhes bibliográficos
Main Authors: Li, Xiaojun, Ranjith-Kumar, C. T., Brooks, Monica T., Dharmaiah, S., Herr, Andrew B., Kao, Cheng, Li, Pingwei
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2679488/
https://ncbi.nlm.nih.gov/pubmed/19278996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M900818200
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