The Structural Basis of 5′ Triphosphate Double-stranded RNA Recognition by RIG-I C-terminal Domain

RIG-I is a cytosolic sensor of viral RNA that plays crucial roles in the induction of type I interferons. The C-terminal domain (CTD) of RIG-I is responsible for the recognition of viral RNA with 5′ triphosphate (5′ ppp). However, the mechanism of viral RNA recognition by RIG-I is still not fully un...

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Main Authors: Lu, Cheng, Xu, Hengyu, Ranjith-Kumar, C. T., Brooks, Monica T., Hou, Tim Y., Hu, Fuqu, Herr, Andrew B., Strong, Roland K., Kao, C. Cheng, Li, Pingwei
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2919622/
https://ncbi.nlm.nih.gov/pubmed/20637642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2010.05.007
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