Recognition of 5′-triphosphate by RIG-I helicase requires short blunt double-stranded RNA as contained in panhandle of negative strand virus

Antiviral immunity is triggered by immunorecognition of viral nucleic acids. The cytosolic helicase RIG-I is a key sensor of viral infections and is activated by RNA containing a triphosphate at the 5′end. The exact structure of RNA activating RIG-I remains controversial. Here we established a chemi...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Schlee, Martin, Roth, Andreas, Hornung, Veit, Hagmann, Cristina Amparo, Wimmenauer, Vera, Barchet, Winfried, Coch, Christoph, Janke, Markus, Mihailovic, Aleksandra, Wardle, Greg, Juranek, Stefan, Kato, Hiroki, Kawai, Taro, Poeck, Hendrik, Fitzgerald, Katherine A., Takeuchi, Osamu, Akira, Shizuo, Tuschl, Thomas, Latz, Eicke, Ludwig, Janos, Hartmann, Gunther
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2009
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2824854/
https://ncbi.nlm.nih.gov/pubmed/19576794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2009.05.008
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