Recognition of 5′-triphosphate by RIG-I helicase requires short blunt double-stranded RNA as contained in panhandle of negative strand virus

Antiviral immunity is triggered by immunorecognition of viral nucleic acids. The cytosolic helicase RIG-I is a key sensor of viral infections and is activated by RNA containing a triphosphate at the 5′end. The exact structure of RNA activating RIG-I remains controversial. Here we established a chemi...

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Detaylı Bibliyografya
Asıl Yazarlar: Schlee, Martin, Roth, Andreas, Hornung, Veit, Hagmann, Cristina Amparo, Wimmenauer, Vera, Barchet, Winfried, Coch, Christoph, Janke, Markus, Mihailovic, Aleksandra, Wardle, Greg, Juranek, Stefan, Kato, Hiroki, Kawai, Taro, Poeck, Hendrik, Fitzgerald, Katherine A., Takeuchi, Osamu, Akira, Shizuo, Tuschl, Thomas, Latz, Eicke, Ludwig, Janos, Hartmann, Gunther
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2009
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2824854/
https://ncbi.nlm.nih.gov/pubmed/19576794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2009.05.008
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