Recognition of 5′-triphosphate by RIG-I helicase requires short blunt double-stranded RNA as contained in panhandle of negative strand virus

Antiviral immunity is triggered by immunorecognition of viral nucleic acids. The cytosolic helicase RIG-I is a key sensor of viral infections and is activated by RNA containing a triphosphate at the 5′end. The exact structure of RNA activating RIG-I remains controversial. Here we established a chemi...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Schlee, Martin, Roth, Andreas, Hornung, Veit, Hagmann, Cristina Amparo, Wimmenauer, Vera, Barchet, Winfried, Coch, Christoph, Janke, Markus, Mihailovic, Aleksandra, Wardle, Greg, Juranek, Stefan, Kato, Hiroki, Kawai, Taro, Poeck, Hendrik, Fitzgerald, Katherine A., Takeuchi, Osamu, Akira, Shizuo, Tuschl, Thomas, Latz, Eicke, Ludwig, Janos, Hartmann, Gunther
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
Soggetti:
Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2824854/
https://ncbi.nlm.nih.gov/pubmed/19576794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2009.05.008
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi