Recognition of 5′-triphosphate by RIG-I helicase requires short blunt double-stranded RNA as contained in panhandle of negative strand virus

Antiviral immunity is triggered by immunorecognition of viral nucleic acids. The cytosolic helicase RIG-I is a key sensor of viral infections and is activated by RNA containing a triphosphate at the 5′end. The exact structure of RNA activating RIG-I remains controversial. Here we established a chemi...

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Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Schlee, Martin, Roth, Andreas, Hornung, Veit, Hagmann, Cristina Amparo, Wimmenauer, Vera, Barchet, Winfried, Coch, Christoph, Janke, Markus, Mihailovic, Aleksandra, Wardle, Greg, Juranek, Stefan, Kato, Hiroki, Kawai, Taro, Poeck, Hendrik, Fitzgerald, Katherine A., Takeuchi, Osamu, Akira, Shizuo, Tuschl, Thomas, Latz, Eicke, Ludwig, Janos, Hartmann, Gunther
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: 2009
Θέματα:
Article
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2824854/
https://ncbi.nlm.nih.gov/pubmed/19576794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2009.05.008
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