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Critical functions of priming and lysosomal damage for NLRP3 activation

Inflammasomes are cytosolic multi-protein complexes that form in response to infectious or injurious challenges. Inflammasomes control the activity of caspase-1, which is essential for the maturation and release of IL-1b family cytokines. The NLRP1, IPAF and AIM2 inflammasomes recognize specific sub...

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Bibliografiske detaljer
Main Authors: Hornung, Veit, Latz, Eicke
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3893565/
https://ncbi.nlm.nih.gov/pubmed/20201015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.200940185
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