Mitochondrial ROS induces NLRP3-dependent lysosomal damage and inflammasome activation()

The NLRP3 inflammasome drives many inflammatory processes and mediates IL-1 family cytokine release. Inflammasome activators typically damage cells, and may release lysosomal and mitochondrial products into the cytosol. Macrophages triggered by the NLRP3 inflammasome activator nigericin show reduced...

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Hauptverfasser: Heid, Michelle E., Keyel, Peter A., Kamga, Christelle, Shiva, Sruti, Watkins, Simon C., Salter, Russell D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3833073/
https://ncbi.nlm.nih.gov/pubmed/24089192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1301490
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