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Mitochondrial ROS induces NLRP3-dependent lysosomal damage and inflammasome activation()
The NLRP3 inflammasome drives many inflammatory processes and mediates IL-1 family cytokine release. Inflammasome activators typically damage cells, and may release lysosomal and mitochondrial products into the cytosol. Macrophages triggered by the NLRP3 inflammasome activator nigericin show reduced...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3833073/ https://ncbi.nlm.nih.gov/pubmed/24089192 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1301490 |
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