Cortistatin protects against intervertebral disc degeneration through targeting mitochondrial ROS-dependent NLRP3 inflammasome activation

Background: Intervertebral disc (IVD) degeneration is a common degenerative disease that can lead to collapse or herniation of the nucleus pulposus (NP) and result in radiculopathy in patients. Methods: NP tissue and cells were isolated from patients and mice, and the expression profile of cortistat...

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Dettagli Bibliografici
Pubblicato in:Theranostics
Autori principali: Zhao, Yunpeng, Qiu, Cheng, Wang, Wenhan, Peng, Jiangfan, Cheng, Xiang, Shangguan, Yangtao, Xu, Mingyang, Li, Jiayi, Qu, Ruize, Chen, Xiaomin, Jia, Suyi, Luo, Dan, Liu, Long, Li, Peng, Guo, Fengjin, Vasilev, Krasimir, Liu, Liang, Hayball, John, Dong, Shuli, Pan, Xin, Li, Yuhua, Guo, Linlin, Cheng, Lei, Li, Weiwei
Natura: Artigo
Lingua:Inglês
Pubblicazione: Ivyspring International Publisher 2020
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7295059/
https://ncbi.nlm.nih.gov/pubmed/32550919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.45359
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