Cholesterol-dependent cytolysins induce rapid release of mature IL-1β from murine macrophages in a NLRP3 inflammasome and cathepsin B-dependent manner

CDC are exotoxins secreted by many Gram-positive bacteria that bind cholesterol and oligomerize to form pores in eukaryotic cell membranes. We demonstrate that CDC TLO induces caspase-1 cleavage and the rapid release of IL-1β from LPS-primed murine BMDM. IL-1β secretion depends on functional toxin p...

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Библиографические подробности
Главные авторы: Chu, Jessica, Thomas, L. Michael, Watkins, Simon C., Franchi, Luigi, Núñez, Gabriel, Salter, Russell D.
Формат: Artigo
Язык:Inglês
Опубликовано: The Society for Leukocyte Biology 2009
Предметы:
Inflammation, Extracellular Mediators, & Effector Molecules
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2774880/
https://ncbi.nlm.nih.gov/pubmed/19675207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.0309164
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