Cholesterol-dependent cytolysins induce rapid release of mature IL-1β from murine macrophages in a NLRP3 inflammasome and cathepsin B-dependent manner

CDC are exotoxins secreted by many Gram-positive bacteria that bind cholesterol and oligomerize to form pores in eukaryotic cell membranes. We demonstrate that CDC TLO induces caspase-1 cleavage and the rapid release of IL-1β from LPS-primed murine BMDM. IL-1β secretion depends on functional toxin p...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Chu, Jessica, Thomas, L. Michael, Watkins, Simon C., Franchi, Luigi, Núñez, Gabriel, Salter, Russell D.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The Society for Leukocyte Biology 2009
Pynciau:
Inflammation, Extracellular Mediators, & Effector Molecules
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2774880/
https://ncbi.nlm.nih.gov/pubmed/19675207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.0309164
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg