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Cholesterol-dependent cytolysins induce rapid release of mature IL-1β from murine macrophages in a NLRP3 inflammasome and cathepsin B-dependent manner
CDC are exotoxins secreted by many Gram-positive bacteria that bind cholesterol and oligomerize to form pores in eukaryotic cell membranes. We demonstrate that CDC TLO induces caspase-1 cleavage and the rapid release of IL-1β from LPS-primed murine BMDM. IL-1β secretion depends on functional toxin p...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Society for Leukocyte Biology
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2774880/ https://ncbi.nlm.nih.gov/pubmed/19675207 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.0309164 |
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