Syk‐dependent glycolytic reprogramming in dendritic cells regulates IL‐1β production to β‐glucan ligands in a TLR‐independent manner

Dendritic cells (DCs) activated via TLR ligation experience metabolic reprogramming, in which the cells are heavily dependent on glucose and glycolysis for the synthesis of molecular building blocks essential for maturation, cytokine production, and the ability to stimulate T cells. Although the TLR...

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Vydáno v:J Leukoc Biol
Hlavní autoři: Thwe, Phyu M., Fritz, Daniel I., Snyder, Julia P., Smith, Portia R., Curtis, Kylie D., O'Donnell, Alexandra, Galasso, Nicholas A., Sepaniac, Leslie A., Adamik, Benjamin J., Hoyt, Laura R., Rodriguez, Princess D., Hogan, Tyler C., Schmidt, Andrea F., Poynter, Matthew E., Amiel, Eyal
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2019
Témata:
Inflammation, Extracellular Mediators, & Effector Molecules
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6883127/
https://ncbi.nlm.nih.gov/pubmed/31509298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/JLB.3A0819-207RR
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