Structural features of influenza A virus panhandle RNA enabling the activation of RIG-I independently of 5′-triphosphate

Retinoic acid-inducible gene I (RIG-I) recognizes specific molecular patterns of viral RNAs for inducing type I interferon. The C-terminal domain (CTD) of RIG-I binds to double-stranded RNA (dsRNA) with the 5′-triphosphate (5′-PPP), which induces a conformational change in RIG-I to an active form. I...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Lee, Mi-Kyung, Kim, Hee-Eun, Park, Eun-Byeol, Lee, Janghyun, Kim, Ki-Hun, Lim, Kyungeun, Yum, Seoyun, Lee, Young-Hoon, Kang, Suk-Jo, Lee, Joon-Hwa, Choi, Byong-Seok
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2016
Assuntos:
RNA
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5041458/
https://ncbi.nlm.nih.gov/pubmed/27288441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw525
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