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5′-Triphosphate-RNA-independent activation of RIG-I via RNA aptamer with enhanced antiviral activity
RIG-I is a cytosolic receptor for non-self RNA that mediates immune responses against viral infections through IFNα/β production. In an attempt to identify novel tools that modulate IFNα/β production, we used SELEX technology to screen RNA aptamers that specifically target RIG-I protein. Most of the...
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| Главные авторы: | , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Oxford University Press
2012
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3315321/ https://ncbi.nlm.nih.gov/pubmed/22127865 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr1098 |
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