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Synthesis of 5-isoxazol-5-yl-2′-deoxyuridines exhibiting antiviral activity against HSV and several RNA viruses
This paper describes a simple method for synthesizing a small library of 5-isoxazol-5-yl-2′-deoxyuridines from 5-iodo-2′-deoxyuridine. Nitrile oxides were generated in situ from oximes using a commercial bleaching agent; their cycloaddition with 5-ethynyl-2′-deoxyuridine yielded isoxazoles possessin...
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| Published in: | Bioorg Med Chem Lett |
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| Main Authors: | , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Published by Elsevier Ltd.
2009
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7126966/ https://ncbi.nlm.nih.gov/pubmed/19147352 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2008.12.103 |
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