5′-Triphosphate-RNA-independent activation of RIG-I via RNA aptamer with enhanced antiviral activity

RIG-I is a cytosolic receptor for non-self RNA that mediates immune responses against viral infections through IFNα/β production. In an attempt to identify novel tools that modulate IFNα/β production, we used SELEX technology to screen RNA aptamers that specifically target RIG-I protein. Most of the...

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Hlavní autoři: Hwang, Sun-Young, Sun, Hwa-Young, Lee, Kwang-Hoon, Oh, Byung-Ha, Cha, Yu Jin, Kim, Byeang Hyean, Yoo, Joo-Yeon
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2012
Témata:
RNA
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3315321/
https://ncbi.nlm.nih.gov/pubmed/22127865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr1098
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