5′-triphosphate RNA requires base-paired structures to activate antiviral signaling via RIG-I

The ATPase retinoid acid-inducible gene (RIG)-I senses viral RNA in the cytoplasm of infected cells and subsequently activates cellular antiviral defense mechanisms. RIG-I recognizes molecular structures that discriminate viral from host RNA. Here, we show that RIG-I ligands require base-paired stru...

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Détails bibliographiques
Auteurs principaux: Schmidt, Andreas, Schwerd, Tobias, Hamm, Wolfgang, Hellmuth, Johannes C., Cui, Sheng, Wenzel, Michael, Hoffmann, Franziska S., Michallet, Marie-Cecile, Besch, Robert, Hopfner, Karl-Peter, Endres, Stefan, Rothenfusser, Simon
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2009
Sujets:
Biological Sciences
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2705279/
https://ncbi.nlm.nih.gov/pubmed/19574455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0900971106
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