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Negative Feedback Regulation of RIG-I-Mediated Antiviral Signaling by Interferon-Induced ISG15 Conjugation

RIG-I senses intracellular virus-specific nucleic acid structures and initiates an antiviral response that induces interferon (IFN) production, which, in turn, activates the transcription of RIG-I to increase RIG-I protein levels. Upon intracellular poly(I:C) stimulation, however, the levels of RIG-...

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Autors principals: Kim, Min-Jung, Hwang, Sun-Young, Imaizumi, Tadaatsu, Yoo, Joo-Yeon
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology (ASM) 2008
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2224411/
https://ncbi.nlm.nih.gov/pubmed/18057259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01650-07
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