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Interferon-Induced ISG15 Conjugation Inhibits Influenza A Virus Gene Expression and Replication in Human Cells

The ubiquitin-like ISG15 protein, as well as its conjugating enzymes, is induced by type I interferons (IFNs). Experiments using ISG15 knockout (ISG15(−/−)) mice established that ISG15 and/or its conjugation inhibits the replication of influenza A virus. However, in contrast to the virus inhibition...

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Hlavní autoři: Hsiang, Tien-Ying, Zhao, Chen, Krug, Robert M.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology (ASM) 2009
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2687383/
https://ncbi.nlm.nih.gov/pubmed/19357168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01667-08
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