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Phosphorylation-Mediated Negative Regulation of RIG-I Antiviral Activity

Recognition of invading viruses by the host is elicited by cellular sensors which trigger signaling cascades that lead to type I interferon (IFN) gene expression. Retinoic acid-inducible gene I (RIG-I) has emerged as a key receptor for the detection of viral RNA in the cytosol, inducing IFN-mediated...

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Autori principali: Gack, Michaela U., Nistal-Villán, Estanislao, Inn, Kyung-Soo, García-Sastre, Adolfo, Jung, Jae U.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology (ASM) 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2838087/
https://ncbi.nlm.nih.gov/pubmed/20071582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02241-09
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