Negative Role of RIG-I Serine 8 Phosphorylation in the Regulation of Interferon-β Production

RIG-I (retinoic acid-inducible gene I) and TRIM25 (tripartite motif protein 25) have emerged as key regulatory factors to induce interferon (IFN)-mediated innate immune responses to limit viral replication. Upon recognition of viral RNA, TRIM25 E3 ligase binds the first caspase recruitment domain (C...

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Autori principali: Nistal-Villán, Estanislao, Gack, Michaela U., Martínez-Delgado, Gustavo, Maharaj, Natalya P., Inn, Kyung-Soo, Yang, Heyi, Wang, Rong, Aggarwal, Aneel K., Jung, Jae U., García-Sastre, Adolfo
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2010
Soggetti:
Signal Transduction
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2888438/
https://ncbi.nlm.nih.gov/pubmed/20406818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.089912
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