Structure and Dynamics of the Second CARD of Human RIG-I Provide Mechanistic Insights into Regulation of RIG-I Activation

RIG-I is a cytosolic sensor of viral RNA, comprised of two N-terminal CARDs followed by helicase and C-terminal regulatory domains (helicase-CTD). Viral RNA binds to the helicase-CTD and “exposes” the CARDs for downstream signaling. The role of the second CARD (CARD2) is essential as RIG-I activatio...

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Autori principali: Ferrage, Fabien, Dutta, Kaushik, Nistal-Villán, Estanislao, Patel, Jenish R., Sánchez-Aparicio, María T., De Ioannes, Pablo, Buku, Angeliki, Aseguinolaza, Gloria González, García-Sastre, Adolfo, Aggarwal, Aneel K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3625992/
https://ncbi.nlm.nih.gov/pubmed/23063562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2012.09.003
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