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Structure and Dynamics of the Second CARD of Human RIG-I Provide Mechanistic Insights into Regulation of RIG-I Activation
RIG-I is a cytosolic sensor of viral RNA, comprised of two N-terminal CARDs followed by helicase and C-terminal regulatory domains (helicase-CTD). Viral RNA binds to the helicase-CTD and “exposes” the CARDs for downstream signaling. The role of the second CARD (CARD2) is essential as RIG-I activatio...
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Main Authors: | , , , , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2012
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3625992/ https://ncbi.nlm.nih.gov/pubmed/23063562 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2012.09.003 |
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