A RIG-I 2CARD-MAVS200 Chimeric Protein Reconstitutes IFN-β Induction and Antiviral Response in Models Deficient in Type I IFN Response

RIG-I-like receptors (RLRs) are cellular sensor proteins that detect certain RNA species produced during viral infections. RLRs activate a signaling cascade that results in the production of IFN-β as well as several other cytokines with antiviral and proinflammatory activities. We explored the poten...

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Pubblicato in:J Innate Immun
Autori principali: Nistal-Villán, Estanislao, Rodríguez-García, Estefanía, Di Scala, Marianna, Ferrero-Laborda, Roberto, Olagüe, Cristina, Vales, África, Carte-Abad, Beatriz, Crespo, Irene, García-Sastre, Adolfo, Prieto, Jesús, Larrea, Esther, González-Aseguinolaza, Gloria
Natura: Artigo
Lingua:Inglês
Pubblicazione: S. Karger AG 2015
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4553127/
https://ncbi.nlm.nih.gov/pubmed/25966783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000375262
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