Solution Structures of Cytosolic RNA Sensor MDA5 and LGP2 C-terminal Domains: IDENTIFICATION OF THE RNA RECOGNITION LOOP IN RIG-I-LIKE RECEPTORS

The RIG-I like receptor (RLR) comprises three homologues: RIG-I (retinoic acid-inducible gene I), MDA5 (melanoma differentiation-associated gene 5), and LGP2 (laboratory of genetics and physiology 2). Each RLR senses different viral infections by recognizing replicating viral RNA in the cytoplasm. T...

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Detalhes bibliográficos
Main Authors: Takahasi, Kiyohiro, Kumeta, Hiroyuki, Tsuduki, Natsuko, Narita, Ryo, Shigemoto, Taeko, Hirai, Reiko, Yoneyama, Mitsutoshi, Horiuchi, Masataka, Ogura, Kenji, Fujita, Takashi, Inagaki, Fuyuhiko
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2719387/
https://ncbi.nlm.nih.gov/pubmed/19380577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.007179
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