The RIG-I ATPase domain structure reveals insights into ATP-dependent antiviral signalling

RIG-I detects cytosolic viral dsRNA with 5′ triphosphates (5′-ppp-dsRNA), thereby initiating an antiviral innate immune response. Here we report the crystal structure of superfamily 2 (SF2) ATPase domain of RIG-I in complex with a nucleotide analogue. RIG-I SF2 comprises two RecA-like domains 1A and...

Descripció completa

Guardat en:
Dades bibliogràfiques
Autors principals: Civril, Filiz, Bennett, Matthew, Moldt, Manuela, Deimling, Tobias, Witte, Gregor, Schiesser, Stefan, Carell, Thomas, Hopfner, Karl-Peter
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2011
Matèries:
Scientific Reports
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3207106/
https://ncbi.nlm.nih.gov/pubmed/21979817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2011.190
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars