ATP hydrolysis by the viral RNA sensor RIG-I prevents unintentional recognition of self-RNA

The cytosolic antiviral innate immune sensor RIG-I distinguishes 5′ tri- or diphosphate containing viral double-stranded (ds) RNA from self-RNA by an incompletely understood mechanism that involves ATP hydrolysis by RIG-I's RNA translocase domain. Recently discovered mutations in ATPase motifs...

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Publicat a:eLife
Autors principals: Lässig, Charlotte, Matheisl, Sarah, Sparrer, Konstantin MJ, de Oliveira Mann, Carina C, Moldt, Manuela, Patel, Jenish R, Goldeck, Marion, Hartmann, Gunther, García-Sastre, Adolfo, Hornung, Veit, Conzelmann, Karl-Klaus, Beckmann, Roland, Hopfner, Karl-Peter
Format: Artigo
Idioma:Inglês
Publicat: eLife Sciences Publications, Ltd 2015
Matèries:
Cell Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4733034/
https://ncbi.nlm.nih.gov/pubmed/26609812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.10859
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