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ATP hydrolysis by the viral RNA sensor RIG-I prevents unintentional recognition of self-RNA
The cytosolic antiviral innate immune sensor RIG-I distinguishes 5′ tri- or diphosphate containing viral double-stranded (ds) RNA from self-RNA by an incompletely understood mechanism that involves ATP hydrolysis by RIG-I's RNA translocase domain. Recently discovered mutations in ATPase motifs...
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| Pubblicato in: | eLife |
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| Autori principali: | , , , , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
eLife Sciences Publications, Ltd
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4733034/ https://ncbi.nlm.nih.gov/pubmed/26609812 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.10859 |
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