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cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING
Detection of cytoplasmic DNA represents one of the most fundamental mechanisms of the innate immune system to sense the presence of microbial pathogens(1). Moreover, erroneous detection of endogenous DNA by the same sensing mechanisms has an important pathophysiological role in certain sterile infla...
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| Main Authors: | , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4143541/ https://ncbi.nlm.nih.gov/pubmed/23722158 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature12306 |
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