cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING

Detection of cytoplasmic DNA represents one of the most fundamental mechanisms of the innate immune system to sense the presence of microbial pathogens(1). Moreover, erroneous detection of endogenous DNA by the same sensing mechanisms has an important pathophysiological role in certain sterile infla...

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Hlavní autoři: Ablasser, Andrea, Goldeck, Marion, Cavlar, Taner, Deimling, Tobias, Witte, Gregor, Röhl, Ingo, Hopfner, Karl-Peter, Ludwig, Janos, Hornung, Veit
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4143541/
https://ncbi.nlm.nih.gov/pubmed/23722158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature12306
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