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Interrupting cyclic dinucleotide-cGAS–STING axis with small molecules
The cyclic dinucleotide-cGAS–STING axis plays important roles in host immunity. Activation of this signaling pathway, via cytosolic sensing of bacterial-derived c-di-GMP/c-di-AMP or host-derived cGAMP, leads to the production of inflammatory interferons and cytokines that help resolve infection. Sma...
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| I publikationen: | Medchemcomm |
|---|---|
| Huvudupphovsmän: | , , , |
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
Royal Society of Chemistry
2019
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7069516/ https://ncbi.nlm.nih.gov/pubmed/32206239 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8md00555a |
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