cGAS facilitates sensing of extracellular cyclic dinucleotides to activate innate immunity

Cyclic dinucleotides (CDNs) are important second messenger molecules in prokaryotes and eukaryotes. Within host cells, cytosolic CDNs are detected by STING and alert the host by activating innate immunity characterized by type I interferon (IFN) responses. Extracellular bacteria and dying cells can...

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發表在:EMBO Rep
Main Authors: Liu, Haipeng, Moura‐Alves, Pedro, Pei, Gang, Mollenkopf, Hans‐Joachim, Hurwitz, Robert, Wu, Xiangyang, Wang, Fei, Liu, Siyu, Ma, Mingtong, Fei, Yiyan, Zhu, Chenggang, Koehler, Anne‐Britta, Oberbeck‐Mueller, Dagmar, Hahnke, Karin, Klemm, Marion, Guhlich‐Bornhof, Ute, Ge, Baoxue, Tuukkanen, Anne, Kolbe, Michael, Dorhoi, Anca, Kaufmann, Stefan HE
格式: Artigo
語言:Inglês
出版: John Wiley and Sons Inc. 2019
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Articles
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6446192/
https://ncbi.nlm.nih.gov/pubmed/30872316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201846293
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