cGAS facilitates sensing of extracellular cyclic dinucleotides to activate innate immunity

Cyclic dinucleotides (CDNs) are important second messenger molecules in prokaryotes and eukaryotes. Within host cells, cytosolic CDNs are detected by STING and alert the host by activating innate immunity characterized by type I interferon (IFN) responses. Extracellular bacteria and dying cells can...

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Publicado en:EMBO Rep
Autores principales: Liu, Haipeng, Moura‐Alves, Pedro, Pei, Gang, Mollenkopf, Hans‐Joachim, Hurwitz, Robert, Wu, Xiangyang, Wang, Fei, Liu, Siyu, Ma, Mingtong, Fei, Yiyan, Zhu, Chenggang, Koehler, Anne‐Britta, Oberbeck‐Mueller, Dagmar, Hahnke, Karin, Klemm, Marion, Guhlich‐Bornhof, Ute, Ge, Baoxue, Tuukkanen, Anne, Kolbe, Michael, Dorhoi, Anca, Kaufmann, Stefan HE
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2019
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6446192/
https://ncbi.nlm.nih.gov/pubmed/30872316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201846293
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