cGAS facilitates sensing of extracellular cyclic dinucleotides to activate innate immunity

Cyclic dinucleotides (CDNs) are important second messenger molecules in prokaryotes and eukaryotes. Within host cells, cytosolic CDNs are detected by STING and alert the host by activating innate immunity characterized by type I interferon (IFN) responses. Extracellular bacteria and dying cells can...

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Библиографические подробности
Опубликовано в: :EMBO Rep
Главные авторы: Liu, Haipeng, Moura‐Alves, Pedro, Pei, Gang, Mollenkopf, Hans‐Joachim, Hurwitz, Robert, Wu, Xiangyang, Wang, Fei, Liu, Siyu, Ma, Mingtong, Fei, Yiyan, Zhu, Chenggang, Koehler, Anne‐Britta, Oberbeck‐Mueller, Dagmar, Hahnke, Karin, Klemm, Marion, Guhlich‐Bornhof, Ute, Ge, Baoxue, Tuukkanen, Anne, Kolbe, Michael, Dorhoi, Anca, Kaufmann, Stefan HE
Формат: Artigo
Язык:Inglês
Опубликовано: John Wiley and Sons Inc. 2019
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Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6446192/
https://ncbi.nlm.nih.gov/pubmed/30872316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201846293
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