cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING

Detection of cytoplasmic DNA represents one of the most fundamental mechanisms of the innate immune system to sense the presence of microbial pathogens(1). Moreover, erroneous detection of endogenous DNA by the same sensing mechanisms has an important pathophysiological role in certain sterile infla...

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Bibliografiska uppgifter
Huvudupphovsmän: Ablasser, Andrea, Goldeck, Marion, Cavlar, Taner, Deimling, Tobias, Witte, Gregor, Röhl, Ingo, Hopfner, Karl-Peter, Ludwig, Janos, Hornung, Veit
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2013
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4143541/
https://ncbi.nlm.nih.gov/pubmed/23722158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature12306
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