Cytosolic RNA:DNA hybrids activate the cGAS–STING axis

Intracellular recognition of non-self and also self-nucleic acids can result in the initiation of potent pro-inflammatory and antiviral cytokine responses. Most recently, cGAS was shown to be critical for the recognition of cytoplasmic dsDNA. Binding of dsDNA to cGAS results in the synthesis of cGAM...

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Détails bibliographiques
Publié dans:EMBO J
Auteurs principaux: Mankan, Arun K, Schmidt, Tobias, Chauhan, Dhruv, Goldeck, Marion, Höning, Klara, Gaidt, Moritz, Kubarenko, Andrew V, Andreeva, Liudmila, Hopfner, Karl-Peter, Hornung, Veit
Format: Artigo
Langue:Inglês
Publié: Blackwell Publishing Ltd 2014
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Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4282641/
https://ncbi.nlm.nih.gov/pubmed/25425575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201488726
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