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Cytosolic DNA sensing through cGAS and STING is inactivated by gene mutations in pangolins

The release of DNA into the cytoplasm upon damage to the nucleus or during viral infection triggers an interferon-mediated defense response, inflammation and cell death. In human cells cytoplasmic DNA is sensed by cyclic GMP-AMP Synthase (cGAS) and Absent In Melanoma 2 (AIM2). Here, we report the id...

詳細記述

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書誌詳細
出版年:Apoptosis
主要な著者: Fischer, Heinz, Tschachler, Erwin, Eckhart, Leopold
フォーマット: Artigo
言語:Inglês
出版事項: Springer US 2020
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7291609/
https://ncbi.nlm.nih.gov/pubmed/32533513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10495-020-01614-4
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