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Cytosolic DNA sensing through cGAS and STING is inactivated by gene mutations in pangolins
The release of DNA into the cytoplasm upon damage to the nucleus or during viral infection triggers an interferon-mediated defense response, inflammation and cell death. In human cells cytoplasmic DNA is sensed by cyclic GMP-AMP Synthase (cGAS) and Absent In Melanoma 2 (AIM2). Here, we report the id...
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| Gepubliceerd in: | Apoptosis |
|---|---|
| Hoofdauteurs: | , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Springer US
2020
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7291609/ https://ncbi.nlm.nih.gov/pubmed/32533513 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10495-020-01614-4 |
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