A Highly Conserved Shh Enhancer Coordinates Hypothalamic and Craniofacial Development

Enhancers that are conserved deep in evolutionary time regulate characteristics held in common across taxonomic classes. Here, deletion of the highly conserved Shh enhancer SBE2 (Shh brain enhancer 2) in mouse markedly reduced Shh expression within the embryonic brain specifically in the rostral die...

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Detalhes bibliográficos
Publicado no:Front Cell Dev Biol
Main Authors: Crane-Smith, Zoe, Schoenebeck, Jeffrey, Graham, Katy A., Devenney, Paul S., Rose, Lorraine, Ditzell, Mark, Anderson, Eve, Thomson, Joseph I., Klenin, Natasha, Kurrasch, Deborah M., Lettice, Laura A., Hill, Robert E.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Cell and Developmental Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8047142/
https://ncbi.nlm.nih.gov/pubmed/33869166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2021.595744
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