Phosphorylation of FE65 at threonine 579 by GSK3β stimulates amyloid precursor protein processing

Por Lee, Yat Shing, Chow, Wan Ning Vanessa, Lau, Kwok-Fai
Publicado no Sci Rep (2017)

An X11α/FSBP complex represses transcription of the GSK3β gene promoter

Por Lau, Kwok-Fai, Perkinton, Michael S., Rodriguez, Lilia, McLoughlin, Declan M., Miller, Christopher C.J.
Publicado em 2010

CAG expansion induces nucleolar stress in polyglutamine diseases

Por Tsoi, Ho, Lau, Terrence Chi-Kong, Tsang, Suk-Ying, Lau, Kwok-Fai, Chan, Ho Yin Edwin
Publicado em 2012

GULP1/CED-6 ameliorates amyloid-β toxicity in a Drosophila model of Alzheimer’s disease

Por Vivien Chiu, Wai Yin, Koon, Alex Chun, Ki Ngo, Jacky Chi, Edwin Chan, Ho Yin, Lau, Kwok-Fai
Publicado no Oncotarget (2017)

Expression of the Neuronal Adaptor Protein X11α Protects Against Memory Dysfunction in a Transgenic Mouse Model of Alzheimer’s Disease

Por Mitchell, Jacqueline C., Perkinton, Michael S., Yates, Darran M., Lau, Kwok-Fai, Rogelj, Boris, Miller, Christopher C.J., McLoughlin, Declan M.
Publicado em 2010

Structural basis of the PE–PPE protein interaction in Mycobacterium tuberculosis

Por Chen, Xin, Cheng, Hiu-fu, Zhou, Junwei, Chan, Chiu-yeung, Lau, Kwok-fai, Tsui, Stephen Kwok-wing, Au, Shannon Wing-ngor
Publicado no J Biol Chem (2017)

Lemur tyrosine kinase-2 signalling regulates kinesin light chain-2 phosphorylation and binding of Smad2 cargo

Por Manser, Catherine, Guillot, Florence, Vagnoni, Alessio, Davies, Jennifer, Lau, Kwok-Fai, McLoughlin, Declan M., De Vos, Kurt J., Miller, Christopher C.J.
Publicado em 2011

FE65 interacts with ADP-ribosylation factor 6 to promote neurite outgrowth

Por Cheung, Hei Nga Maggie, Dunbar, Charlotte, Mórotz, Gábor M., Cheng, Wai Hang, Chan, Ho Yin Edwin, Miller, Christopher C. J., Lau, Kwok-Fai
Publicado no FASEB J (2013)

Assessing a peptidylic inhibitor-based therapeutic approach that simultaneously suppresses polyglutamine RNA- and protein-mediated toxicities in patient cells and Drosophila

Por Zhang, Qian, Tsoi, Ho, Peng, Shaohong, Li, Pan P., Lau, Kwok-Fai, Rudnicki, Dobrila D., Ngo, Jacky Chi-Ki, Chan, Ho Yin Edwin
Publicado no Dis Model Mech (2016)

Nucleophosmin Interacts with PIN2/TERF1-interacting Telomerase Inhibitor 1 (PinX1) and Attenuates the PinX1 Inhibition on Telomerase Activity

Por Cheung, Derek Hang-Cheong, Ho, Sai-Tim, Lau, Kwok-Fai, Jin, Rui, Wang, Ya-Nan, Kung, Hsiang-Fu, Huang, Jun-Jian, Shaw, Pang-Chui
Publicado no Sci Rep (2017)

Neuronal adaptor FE65 stimulates Rac1-mediated neurite outgrowth by recruiting and activating ELMO1

Por Li, Wen, Tam, Ka Ming Vincent, Chan, Wai Wa Ray, Koon, Alex Chun, Ngo, Jacky Chi Ki, Chan, Ho Yin Edwin, Lau, Kwok-Fai
Publicado no J Biol Chem (2018)

VAPB interacts with the mitochondrial protein PTPIP51 to regulate calcium homeostasis

Por De Vos, Kurt J., Mórotz, Gábor M., Stoica, Radu, Tudor, Elizabeth L., Lau, Kwok-Fai, Ackerley, Steven, Warley, Alice, Shaw, Christopher E., Miller, Christopher C.J.
Publicado em 2012

A peptidylic inhibitor for neutralizing expanded CAG RNA-induced nucleolar stress in polyglutamine diseases

Por Zhang, Qian, Chen, Zhefan Stephen, An, Ying, Liu, Haizhen, Hou, Yonghui, Li, Wen, Lau, Kwok-Fai, Koon, Alex Chun, Ngo, Jacky Chi Ki, Chan, Ho Yin Edwin
Publicado no RNA (2018)

X11β rescues memory and long-term potentiation deficits in Alzheimer's disease APPswe Tg2576 mice

Por Mitchell, Jacqueline C., Ariff, Belall B., Yates, Darran M., Lau, Kwok-Fai, Perkinton, Michael S., Rogelj, Boris, Stephenson, John D., Miller, Christopher C.J., McLoughlin, Declan M.
Publicado em 2009

Dexras1 Interacts with FE65 to Regulate FE65-Amyloid Precursor Protein-dependent Transcription

Por Lau, Kwok-Fai, Chan, Wing-Man, Perkinton, Michael S., Tudor, Elizabeth L., Chang, Raymond C. C., Chan, H.-Y. Edwin, McLoughlin, Declan M., Miller, Christopher C. J.
Publicado em 2008

Phosphorylation of FE65 Ser(610) by serum- and glucocorticoid-induced kinase 1 modulates Alzheimer's disease amyloid precursor protein processing

Por Chow, Wan Ning Vanessa, Ngo, Jacky Chi Ki, Li, Wen, Chen, Yu Wai, Tam, Ka Ming Vincent, Chan, Ho Yin Edwin, Miller, Christopher C.J., Lau, Kwok-Fai
Publicado no Biochem J (2015)

Influenza Polymerase Activity Correlates with the Strength of Interaction between Nucleoprotein and PB2 through the Host-Specific Residue K/E627

Por Ng, Andy Ka-Leung, Chan, Wai-Hon, Choi, Sze-Ting, Lam, Mandy Ka-Han, Lau, Kwok-Fai, Chan, Paul Kay-Sheung, Au, Shannon Wing-Ngor, Fodor, Ervin, Shaw, Pang-Chui
Publicado em 2012

The lysosomal protein cathepsin L is a progranulin protease

Por Lee, Chris W., Stankowski, Jeannette N., Chew, Jeannie, Cook, Casey N., Lam, Ying-Wai, Almeida, Sandra, Carlomagno, Yari, Lau, Kwok-Fai, Prudencio, Mercedes, Gao, Fen-Biao, Bogyo, Matthew, Dickson, Dennis W., Petrucelli, Leonard
Publicado no Mol Neurodegener (2017)

Three SpoA-domain proteins interact in the creation of the flagellar type III secretion system in Helicobacter pylori

Por Lam, Kwok Ho, Xue, Chaolun, Sun, Kailei, Zhang, Huawei, Lam, Wendy Wai Ling, Zhu, Zeyu, Ng, Juliana Tsz Yan, Sause, William E., Lertsethtakarn, Paphavee, Lau, Kwok Fai, Ottemann, Karen M., Au, Shannon Wing Ngor
Publicado no J Biol Chem (2018)

Planar cell polarity gene Fuz triggers apoptosis in neurodegenerative disease models

Por Chen, Zhefan Stephen, Li, Li, Peng, Shaohong, Chen, Francis M, Zhang, Qian, An, Ying, Lin, Xiao, Li, Wen, Koon, Alex Chun, Chan, Ting‐Fung, Lau, Kwok‐Fai, Ngo, Jacky Chi Ki, Wong, Wing Tak, Kwan, Kin Ming, Chan, Ho Yin Edwin
Publicado no EMBO Rep (2018)