γ-Secretase Dependent Production of Intracellular Domains Is Reduced in Adult Compared to Embryonic Rat Brain Membranes

بواسطة Frånberg, Jenny, Karlström, Helena, Winblad, Bengt, Tjernberg, Lars O., Frykman, Susanne
منشور في 2010

A CADASIL-mutated Notch 3 receptor exhibits impaired intracellular trafficking and maturation but normal ligand-induced signaling

بواسطة Karlström, Helena, Beatus, Paul, Dannaeus, Karin, Chapman, Gavin, Lendahl, Urban, Lundkvist, Johan
منشور في 2002

Specificity of presenilin‐1‐ and presenilin‐2‐dependent γ‐secretases towards substrate processing

بواسطة Stanga, Serena, Vrancx, Céline, Tasiaux, Bernadette, Marinangeli, Claudia, Karlström, Helena, Kienlen‐Campard, Pascal
الحاوية / القاعدة J Cell Mol Med (2017)

Mutations in Nicastrin Protein Differentially Affect Amyloid β-Peptide Production and Notch Protein Processing

بواسطة Pamrén, Annelie, Wanngren, Johanna, Tjernberg, Lars O., Winblad, Bengt, Bhat, Ratan, Näslund, Jan, Karlström, Helena
منشور في 2011

Visualizing Active Enzyme Complexes Using a Photoreactive Inhibitor for Proximity Ligation – Application on γ-Secretase

بواسطة Schedin-Weiss, Sophia, Inoue, Mitsuhiro, Teranishi, Yasuhiro, Yamamoto, Natsuko Goto, Karlström, Helena, Winblad, Bengt, Tjernberg, Lars O.
منشور في 2013

γ-secretase complexes containing caspase-cleaved presenilin-1 increase intracellular Aβ(42)/Aβ(40) ratio

بواسطة Hedskog, Louise, Petersen, Camilla A Hansson, Svensson, Annelie I, Welander, Hedvig, Tjernberg, Lars O, Karlström, Helena, Ankarcrona, Maria
الحاوية / القاعدة J Cell Mol Med (2011)

Mitofusin‐2 knockdown increases ER–mitochondria contact and decreases amyloid β‐peptide production

بواسطة Leal, Nuno Santos, Schreiner, Bernadette, Pinho, Catarina Moreira, Filadi, Riccardo, Wiehager, Birgitta, Karlström, Helena, Pizzo, Paola, Ankarcrona, Maria
الحاوية / القاعدة J Cell Mol Med (2016)

Notch receptor cleavage depends on but is not directly executed by presenilins

بواسطة Taniguchi, Yoshihito, Karlström, Helena, Lundkvist, Johan, Mizutani, Tomohiko, Otaka, Akira, Vestling, Monica, Bernstein, Alan, Donoviel, Dorit, Lendahl, Urban, Honjo, Tasuku
منشور في 2002

The Large Hydrophilic Loop of Presenilin 1 Is Important for Regulating γ-Secretase Complex Assembly and Dictating the Amyloid β Peptide (Aβ) Profile without Affecting Notch Process...

بواسطة Wanngren, Johanna, Frånberg, Jenny, Svensson, Annelie I., Laudon, Hanna, Olsson, Fredrik, Winblad, Bengt, Liu, Frank, Näslund, Jan, Lundkvist, Johan, Karlström, Helena
منشور في 2010

Changed membrane integration and catalytic site conformation are two mechanisms behind the increased Aβ42/Aβ40 ratio by presenilin 1 familial Alzheimer-linked mutations

بواسطة Wanngren, Johanna, Lara, Patricia, Öjemalm, Karin, Maioli, Silvia, Moradi, Nasim, Chen, Lu, Tjernberg, Lars O., Lundkvist, Johan, Nilsson, IngMarie, Karlström, Helena
منشور في 2014

Novel Cysteine-Sparing Hypomorphic NOTCH3 A1604T Mutation Observed in a Family With Migraine and White Matter Lesions

بواسطة Arnardottir, Snjolaug, Del Gaudio, Francesca, Klironomos, Stefanos, Braune, Eike-Benjamin, Lombraña, Ariane Araujo, Oliveira, Daniel V., Jin, Shaobo, Karlström, Helena, Lendahl, Urban, Sjöstrand, Christina
الحاوية / القاعدة Neurol Genet (2021)

The infantile myofibromatosis NOTCH3 L1519P mutation leads to hyperactivated ligand-independent Notch signaling and increased PDGFRB expression

بواسطة Wu, Dan, Wang, Sailan, Oliveira, Daniel V., Del Gaudio, Francesca, Vanlandewijck, Michael, Lebouvier, Thibaud, Betsholtz, Christer, Zhao, Jian, Jin, ShaoBo, Lendahl, Urban, Karlström, Helena
الحاوية / القاعدة Dis Model Mech (2021)

Differences in proliferation rate between CADASIL and control vascular smooth muscle cells are related to increased TGFβ expression

بواسطة Panahi, Mahmod, Yousefi Mesri, Naeimeh, Samuelsson, Eva‐Britt, Coupland, Kirsten G., Forsell, Charlotte, Graff, Caroline, Tikka, Saara, Winblad, Bengt, Viitanen, Matti, Karlström, Helena, Sundström, Erik, Behbahani, Homira
الحاوية / القاعدة J Cell Mol Med (2018)

Second Generation γ-Secretase Modulators Exhibit Different Modulation of Notch β and Aβ Production

بواسطة Wanngren, Johanna, Ottervald, Jan, Parpal, Santiago, Portelius, Erik, Strömberg, Kia, Borgegård, Tomas, Klintenberg, Rebecka, Juréus, Anders, Blomqvist, Jenny, Blennow, Kaj, Zetterberg, Henrik, Lundkvist, Johan, Rosqvist, Susanne, Karlström, Helena
منشور في 2012

Alzheimer's Disease: Presenilin 2-Sparing γ-Secretase Inhibition Is a Tolerable Aβ Peptide-Lowering Strategy

بواسطة Borgegård, Tomas, Gustavsson, Susanne, Nilsson, Charlotte, Parpal, Santiago, Klintenberg, Rebecka, Berg, Anna-Lena, Rosqvist, Susanne, Serneels, Lutgarde, Svensson, Samuel, Olsson, Fredrik, Jin, Shaobo, Yan, Hongmei, Wanngren, Johanna, Jureus, Anders, Ridderstad-Wollberg, Anna, Wollberg, Patrik, Stockling, Kenneth, Karlström, Helena, Malmberg, Åsa, Lund, Johan, Arvidsson, Per I., De Strooper, Bart, Lendahl, Urban, Lundkvist, Johan
الحاوية / القاعدة J Neurosci (2012)