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A CADASIL-mutated Notch 3 receptor exhibits impaired intracellular trafficking and maturation but normal ligand-induced signaling

Notch receptors are single transmembrane receptors that contain a large number of epidermal growth factor-like repeats (EGF repeats) in their extracellular domains. Mutations in the EGF repeats of the human Notch 3 receptor lead to the vascular dementia disease Cerebral Autosomal Dominant Arteriopat...

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Bibliografische gegevens
Hoofdauteurs: Karlström, Helena, Beatus, Paul, Dannaeus, Karin, Chapman, Gavin, Lendahl, Urban, Lundkvist, Johan
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2002
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC139279/
https://ncbi.nlm.nih.gov/pubmed/12482954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.252624099
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