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Notch receptor cleavage depends on but is not directly executed by presenilins
Notch receptors undergo three distinct proteolytic cleavages during maturation and activation. The third cleavage occurs within the plasma membrane and results in the release and translocation of the intracellular domain into the nucleus to execute Notch signaling. This so-called γ-secretase cleavag...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The National Academy of Sciences
2002
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC122640/ https://ncbi.nlm.nih.gov/pubmed/11891288 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.052017699 |
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