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Notch receptor cleavage depends on but is not directly executed by presenilins

Notch receptors undergo three distinct proteolytic cleavages during maturation and activation. The third cleavage occurs within the plasma membrane and results in the release and translocation of the intracellular domain into the nucleus to execute Notch signaling. This so-called γ-secretase cleavag...

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Bibliografische gegevens
Hoofdauteurs: Taniguchi, Yoshihito, Karlström, Helena, Lundkvist, Johan, Mizutani, Tomohiko, Otaka, Akira, Vestling, Monica, Bernstein, Alan, Donoviel, Dorit, Lendahl, Urban, Honjo, Tasuku
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The National Academy of Sciences 2002
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC122640/
https://ncbi.nlm.nih.gov/pubmed/11891288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.052017699
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