Presenilin-mediated transmembrane cleavage is required for Notch signal transduction in Drosophila
The cleavage model for signal transduction by receptors of the LIN-12/Notch family posits that ligand binding leads to cleavage within the transmembrane domain, so that the intracellular domain is released to translocate to the nucleus and activate target gene expression. The familial Alzheimer's di...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2000
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC14573/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11134525/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.011530298 |
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