Assessment of normal and mutant human presenilin function in Caenorhabditis elegans

We provide evidence that normal human presenilins can substitute for Caenorhabditis elegans SEL-12 protein in functional assays in vivo. In addition, six familial Alzheimer disease-linked mutant human presenilins were tested and found to have reduced ability to rescue the sel-12 mutant phenotype, su...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Levitan, Diane, Doyle, Timothy G., Brousseau, Denise, Lee, Michael K., Thinakaran, Gopal, Slunt, Hilda H., Sisodia, Sangram S., Greenwald, Iva
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1996
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC26241/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8962160/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.25.14940
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