Additional evidence for an eight-transmembrane-domain topology for Caenorhabditis elegans and human presenilins
Presenilins have been implicated in the genesis of Alzheimer’s disease and in facilitating LIN-12/Notch activity during development. All presenilins have multiple hydrophobic regions that could theoretically span a membrane, and a description of the membrane topology is a crucial step toward deducin...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1998
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC22757/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9618547/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.12.7109 |
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