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Additional evidence for an eight-transmembrane-domain topology for Caenorhabditis elegans and human presenilins

Presenilins have been implicated in the genesis of Alzheimer’s disease and in facilitating LIN-12/Notch activity during development. All presenilins have multiple hydrophobic regions that could theoretically span a membrane, and a description of the membrane topology is a crucial step toward deducin...

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Bibliografski detalji
Glavni autori: Li, Xiajun, Greenwald, Iva
Format: Artigo
Jezik:Inglês
Izdano: The National Academy of Sciences 1998
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC22757/
https://ncbi.nlm.nih.gov/pubmed/9618547
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